Calorie restriction alters mitochondrial protein acetylation

Calorie restriction alters mitochondrial protein acetylation.

Calorie restriction (CR) increases lifespan in organisms ranging from budding yeast through mammals. Mitochondrial adaptation represents a key component of the response to CR. Molecular mechanisms underlying this adaptation are largely unknown. Here we show that lysine acetylation of mitochondrial proteins is altered during CR in a tissue-specific fashion. Via large-scale mass spectrometry scre...

Restricted mitochondrial protein acetylation initiates mitochondrial autophagy.

Because nutrient-sensing nuclear and cytosolic acetylation mediates cellular autophagy, we investigated whether mitochondrial acetylation modulates mitochondrial autophagy (mitophagy). Knockdown of GCN5L1, a component of the mitochondrial acetyltransferase machinery, diminished mitochondrial protein acetylation and augmented mitochondrial enrichment of autophagy mediators. This program was disr...

Mitochondrial protein acetylation regulates metabolism.

Changes in cellular nutrient availability or energy status induce global changes in mitochondrial protein acetylation. Over one-third of all proteins in the mitochondria are acetylated, of which the majority are involved in some aspect of energy metabolism. Mitochondrial protein acetylation is regulated by SIRT3 (sirtuin 3), a member of the sirtuin family of NAD+-dependent protein deacetylases ...

Calorie Restriction, Longevity and Cognitive Function

Calorie Restriction

Calorie restriction, or caloric restriction (CR), is a dietary regimen thought to improve health and slow the aging process in some animals and fungi by limiting dietary energy intake below the average needs. CR is the only dietary intervention which has been documented to increase both the median and maximum lifespan in a variety of species, among them rodents, yeast, fishes and dogs. The life...